Evaluating therapeutic potential of coriander seeds and leaves (Coriandrum sativum L.) to mitigate carbon tetrachloride-induced hepatotoxicity in rabbits

Objective:To evaluate the hepatic and renal protective potential of coriander seeds and leaves using animal feed model.Methods:Coriander seeds- and leaves-based sauces were administrated to normal (Study I) and carbon tetrachloride (2 mL/kg B.W.)-induced hepatotoxic rabbits (Study II). Hepatic and renal biomarkers like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, superoxide dismutase and catalase were measured.Results:Coriander leaves-based sauce exerted more decline (P<0.05) in serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels in the study II as 18.32%, 19.91% and 21.24%, respectively. While, hepatic superoxide dismutase and catalase levels were raised significantly (P<0.05) in both studies. Renal parameters also depicted positive impact by the provision of developed sauces.Conclusions:Coriander seeds and leaves based sauces are effective in alleviating the hepato/renal toxicity. The hepatoprotective effect of coriander leaves is more pronounced as compared to coriander seeds.

Complications and mortality in ST-segment elevation acute myocardial infarction in diabetic and non-diabetic patients

The difference in environmental conditions along with foods in the subcontinent than other parts of the world incited this work to see how complications and outcome differ in diabetic and non-diabetic patients. 240 patients [76 diabetic and 164 non-diabetic] suffering from ST-segment Elevation acute myocardia infarction were included in the study. Complications of Acute Myocardial Infarction [AMI] and the outcome were compared between diabetics and non-diabetic patients. Different complications studied varied significantly [P<0.001] within diabetics, non-diabetics and in overall after controlling for diabetes. Complications showed similar pattern [heterogeneity test P>0.5] in diabetic and non-diabetic patients. The abnormalities including Cardiogenic shock [OR = 1.9; 95% CI=0.85-4.22], left ventricular failure [OR = 2.5], re-infarction [OR=2.2], arrhythmia [OR=2.04] and ventricular septal defect [OR=2.17] were 4.2, 21.3, 4.2 and 85.24 times higher in diabetics, respectively. However, occurrence of post myocardial angina [OR=0.38] was low in diabetics than non-diabetics. Odds of having diastolic dysfunction were 1.8 times higher in diabetic patients. The moderate and severe LV-dysfunction was 3.3 and 2.5 times higher diabetics, while mild LV-dysfunction in was 2.1 times higher in non-diabetics. Mortality due to STEMI in diabetics was 2.3 times higher than in non-diabetics. Mortality varied significantly between different age groups in non-diabetics and in overall after controlling for diabetes. In non-diabetic group, mortality was 8.4 times higher in patients those were not given streptokinase than those were given streptokinase, while in diabetic group it was 2.5 times higher in patients were not given streptokinase than those were given streptokinase. The results indicate that the diabetics have higher risk of mortality. Inferior infarction is more serious in diabetics than non-diabetics and chances of survival in streptokinase treated patients is five times in non-diabetic while it about two times in diabetics. The results suggest the importance of streptokinase treatment in patients having ST-segment Elevation Acute Myocardial Infarction

Acute myocardial infarction: In hospital mortality of consecutive 275 parents

OBJECTIVE: To highlight the mortality in various groups of acute myocardial infarction. DESIGN: Retrospective study. SETTING: Coronary care Unit DHQ Hospital Faisalabad. PERIOD: January 1995 to December 1995. PATIENTS AND METHODS: Total number of patients were 275, males 223, Female 52. Mean age was 54.85 +/- 13.57 years, mean age of males was 53.52 +/- 13.61 and for females 60.55 +/- 11.91 years. Presented with typical chest pain of Ischaemic heart disease for more than 30 minutes. Diagnosed by history, physical examination, 12 lead electrocardiography and rise of cardiac enzymes. From the 275 patients, 102 were from inferior wall, 109 from anteroseptal and 64 were from extensive anterior wall myocardial infarction. Forty two [15%] patients expired during hospital stay, 13[12.74%], 14[12.80%] and 15[23.40%] patients expired from inferior, anteroseptal and extensive anterior wall myocardial infarction respectively. CONCLUSIONS: Mortality associated with acute anteroseptal MI and extensive anterior wall myocardial infarction was significantly higher, so these patients be monitored and managed more aggressively